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Symbol
Name
ID 		Sox9
SRY (sex determining region Y)-box 9
MGI:98371
Phenotype annotations related to respiratory system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Recurrent upper respiratory tract infections
Recurrent lower respiratory tract infections
Stridor
Apnea
Respiratory distress
Alveolar cell carcinoma
Non-small cell lung carcinoma
Lung adenocarcinoma
Tracheobronchomalacia
Tracheomalacia
Laryngomalacia
Respiratory insufficiency
Neonatal respiratory distress
Disease(s) Associated with SOX9
campomelic dysplasia
lung cancer

Mouse Phenotypes
respiratory system phenotype
absent nasal capsule
lung cyst
abnormal laryngeal cartilage morphology
absent thyroid cartilage
abnormal lung morphology
abnormal branching involved in lung morphogenesis
abnormal lung epithelium morphology
abnormal pulmonary alveolus epithelium morphology
small lung
abnormal tracheal cartilage morphology
abnormal respiration
respiratory distress
Availability Mouse Genotype
Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sor+
Tg(SFTPC-rtTA)5Jaw/0
Sox9tm1Crm/Sox9+
Sox9tm1Gsr/Sox9tm1Gsr
Tg(Col2a1-cre)1Bhr/0  (conditional)
Sox9tm1Gsr/Sox9tm1Gsr
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0  (conditional)		 *
Sox9tm1Gsr/Sox9tm1Gsr
Shhtm1(EGFP/cre)Cjt/Shh+  (conditional)
Sox9tm2Crm/Sox9tm2Crm
Tg(Prrx1-cre)1Cjt/0  (conditional)
Sox9tm2Crm/Sox9tm2Crm
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Gt(ROSA)26Sortm1(tetO-Sox9)Msan/Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy
Shhtm1(EGFP/cre)Cjt/Shh+  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory